ABSTRACT
Amyloidosis represents diseases, causing abnormal Amyloid precipitations. It is a rare condition with unknown origin that may be associated with abnormal production of Immunoglobulin by plasma cells. Skin presentations consist of papule and plaques, usually in axillary's folds, perianal, facials and neck regions. Most patients develop peripheral nerves engagement in the form of paresthesia and autonomic involvement. Primary Amyloidosis may remain asymptomatic, as far as extensive tissues destructions develop. This article is due to report a rare case of primary Amyloidosis with the involvement of skin and peripheral nerves. A 62 years old man with fatigue, anorexia, weight loss, acute diarrehea, and periodic attacks of consciousness loss. Skin lesions as echimosis and telangioectasia in the cheeks, nose, around the eyes and on the front of neck, were presented.The patient had sensorial polyneuropathy. The spleen was larger than normal.These was a brief increase in the serum gamaglobulins. Rectum and bone marrow biopsy were normal, but skin biopsy showed Amyloidosis